Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes

The P2 aminopurine transporter, encoded by TbAT1 in African trypanosomes in the Trypanosoma brucei group, carries melaminophenyl arsenical and diamidine drugs into these parasites. Loss of this transporter contributes to drug resistance. We identified the genomic location of TbAT1 to be in the subte...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Stewart, Mhairi L., Burchmore, Richard J. S., Clucas, Caroline, Hertz-Fowler, Christiane, Brooks, Karen, Tait, A., MacLeod, A., Turner, C. Michael R., De Koning, Harry P., Wong, Pui Ee, Barrett, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2010
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823006/
https://ncbi.nlm.nih.gov/pubmed/19966032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00200-09
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky