Inhibition of transforming growth factor-β signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart

This study utilized a transgenic mouse model that expresses an inducible dominant-negative mutation of the transforming growth factor (TGF)-β type II receptor (DnTGFβRII) to define the structural and functional responses of the left ventricle (LV) to pressure-overload stress in the absence of an int...

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Detalhes bibliográficos
Main Authors: Lucas, Jason A., Zhang, Yun, Li, Peng, Gong, Kaizheng, Miller, Andrew P., Hassan, Erum, Hage, Fadi, Xing, Dongqi, Wells, Bryan, Oparil, Suzanne, Chen, Yiu-Fai
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822586/
https://ncbi.nlm.nih.gov/pubmed/19933419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00529.2009
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