cGMP Inhibits TGF-β Signaling by Sequestering Smad3 with Cytosolic β2-Tubulin in Pulmonary Artery Smooth Muscle Cells

Atrial natriuretic peptide (ANP) and TGF-β play counterregulatory roles in pulmonary vascular adaptation to chronic hypoxia. We have demonstrated that ANP-cyclic GMP (cGMP)-protein kinase G (PKG) signaling inhibits TGF-β signaling by blocking TGF-β-induced nuclear translocation of mothers against de...

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Detalhes bibliográficos
Main Authors: Gong, Kaizheng, Xing, Dongqi, Li, Peng, Hilgers, Robert H., Hage, Fadi G., Oparil, Suzanne, Chen, Yiu-Fai
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182417/
https://ncbi.nlm.nih.gov/pubmed/21868450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1009
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