OCRL1 function in renal epithelial membrane traffic

The X-linked disorder Lowe syndrome arises from mutations in OCRL1, a lipid phosphatase that hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP(2)). Most patients with Lowe syndrome develop proteinuria very early in life. PIP(2) dynamics are known to modulate numerous steps in membrane traffickin...

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Autores principales: Cui, Shanshan, Guerriero, Christopher J., Szalinski, Christina M., Kinlough, Carol L., Hughey, Rebecca P., Weisz, Ora A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822509/
https://ncbi.nlm.nih.gov/pubmed/19940034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00453.2009
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