Phosphatidylinositol 4,5-bisphosphate and loss of PLCγ activity inhibit TRPM channels required for oscillatory Ca(2+) signaling

The Caenorhabditis elegans intestinal epithelium generates rhythmic inositol 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) oscillations that control muscle contractions required for defecation. Two highly Ca(2+)-selective transient receptor potential (TRP) melastatin (TRPM) channels, GON-2 and GTL-1,...

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Bibliographische Detailangaben
Hauptverfasser: Xing, Juan, Strange, Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2009
Schlagworte:
Membrane Transporters, Ion Channels and Pumps
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822497/
https://ncbi.nlm.nih.gov/pubmed/19923421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00394.2009
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