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The(Q1) Influence of Innate and Pre-Existing Immunity on Adenovirus Therapy
Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However, innate immune responses to adenovirus vectors limit effectiveness of Ad5 based therapies. Moreover, extensive pre-existing Ad5 immunity in huma...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822460/ https://ncbi.nlm.nih.gov/pubmed/19711370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22328 |
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