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Somatic mutations in PI3Kα: structural basis for the enzyme activation and drug design
The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3Kα harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821964/ https://ncbi.nlm.nih.gov/pubmed/19962457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.11.020 |
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