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Selection-Driven Immune Escape Is Not a Significant Factor in the Failure of CD4 T Cell Responses in Persistent Hepatitis C Virus Infection

Immune escape driven by selection pressure from virus-specific CD8 T cells has been demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV). Although escape mutations have also been characterized in major histocompatibility complex (MHC) class II–restricted HCV epitopes...

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Detalhes bibliográficos
Main Authors: Fuller, Michael J., Shoukry, Naglaa H., Gushima, Toshifumi, Bowen, David G., Callendret, Benoit, Campbell, Katherine J., Hasselschwert, Dana L., Hughes, Austin L., Walker, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821874/
https://ncbi.nlm.nih.gov/pubmed/19918975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23319
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