Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish persistence in chronically infected individuals are not clear. Mutations in human leukocyte antigen (HLA) class I-restricted epitopes targeted by CD8(+) T cells are associated with persistence, but the extent to which...

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Hlavní autoři: Uebelhoer, Luke, Han, Jin-Hwan, Callendret, Benoit, Mateu, Guaniri, Shoukry, Naglaa H., Hanson, Holly L., Rice, Charles M., Walker, Christopher M., Grakoui, Arash
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518852/
https://ncbi.nlm.nih.gov/pubmed/18773115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000143
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