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MMP-9 functions as a tumor suppressor in colitis-associated cancer
We have demonstrated that epithelial derived MMP-9 is upregulated during inflammatory bowel disease, mediates tissue damage during colitis and regulates goblet cell differentiation through proteoltic cleavage of Notch-1 in colon. Association of MMP-9 and Notch-1 with colon cancer has been well docum...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821688/ https://ncbi.nlm.nih.gov/pubmed/20068187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3166 |
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