MMP-9 functions as a tumor suppressor in colitis-associated cancer

We have demonstrated that epithelial derived MMP-9 is upregulated during inflammatory bowel disease, mediates tissue damage during colitis and regulates goblet cell differentiation through proteoltic cleavage of Notch-1 in colon. Association of MMP-9 and Notch-1 with colon cancer has been well docum...

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Bibliografiske detaljer
Main Authors:	Garg, Pallavi, Sarma, Dittakavi, Jeppsson, Sabrina, Patel, Neal R, Gewirtz, Andrew T, Merlin, Didier, Sitaraman, Shanthi V
Format:	Artigo
Sprog:	Inglês
Udgivet:	2010
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2821688/ https://ncbi.nlm.nih.gov/pubmed/20068187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3166
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MMP-9 functions as a tumor suppressor in colitis-associated cancer

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