Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis

Colitis associated cancer (CAC) is chronic inflammation driven colon cancer, prevalent among individuals with Inflammatory Bowel Disease. Matrix-metalloproteinase (MMP9) is one of the essential regulators of extra cellular matrix components. We have shown that MMP9 is protective in CAC contrary to i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Walter, Lewins, Pujada, Adani, Bhatnagar, Noopur, Bialkowska, Agnieszka B, Yang, Vincent W., Laroui, Hamed, Garg, Pallavi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352126/
https://ncbi.nlm.nih.gov/pubmed/27861153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13406
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