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Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: An enzyme directed prodrug approach
The aim of this study was to identify a phenolic prodrug compound that is minimally metabolized by rat liver microsomes, but yet could form quinone reactive intermediates in melanoma cells as a result of its bioactivation by tyrosinase. In current work, we investigated 24 phenolic compounds for thei...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821678/ https://ncbi.nlm.nih.gov/pubmed/19944085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2009.11.020 |
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