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Aquaporin-1 Tunes Pain Perception by Interaction with Na(v)1.8 Na(+) Channels in Dorsal Root Ganglion Neurons

Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons. We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(−/−) versus AQP1(+/+) mice. Behavioral studies showed greatly reduced thermal inflammatory pain percepti...

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Detalhes bibliográficos
Main Authors: Zhang, Hua, Verkman, A. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820815/
https://ncbi.nlm.nih.gov/pubmed/20018876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090233
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