Native-unlike Long-lived Intermediates along the Folding Pathway of the Amyloidogenic Protein β(2)-Microglobulin Revealed by Real-time Two-dimensional NMR

β2-microglobulin (β2m), the light chain of class I major histocompatibility complex, is responsible for the dialysis-related amyloidosis and, in patients undergoing long term dialysis, the full-length and chemically unmodified β2m converts into amyloid fibrils. The protein, belonging to the immunogl...

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Détails bibliographiques
Auteurs principaux: Corazza, Alessandra, Rennella, Enrico, Schanda, Paul, Mimmi, Maria Chiara, Cutuil, Thomas, Raimondi, Sara, Giorgetti, Sofia, Fogolari, Federico, Viglino, Paolo, Frydman, Lucio, Gal, Maayan, Bellotti, Vittorio, Brutscher, Bernhard, Esposito, Gennaro
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820808/
https://ncbi.nlm.nih.gov/pubmed/20028983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061168
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