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Molecular Dynamics Simulation Suggests Possible Interaction Patterns at Early Steps of β(2)-Microglobulin Aggregation

Early events in aggregation of proteins are not easily accessible by experiments. In this work, we perform a 5-ns molecular dynamics simulation of an ensemble of 27 copies of β(2)-microglobulin in explicit solvent. During the simulation, the formation of intermolecular contacts is observed. The simu...

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Detalhes bibliográficos
Main Authors: Fogolari, Federico, Corazza, Alessandra, Viglino, Paolo, Zuccato, Pierfrancesco, Pieri, Lidia, Faccioli, Pietro, Bellotti, Vittorio, Esposito, Gennaro
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796822/
https://ncbi.nlm.nih.gov/pubmed/17158575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098483
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