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Native-unlike Long-lived Intermediates along the Folding Pathway of the Amyloidogenic Protein β(2)-Microglobulin Revealed by Real-time Two-dimensional NMR
β2-microglobulin (β2m), the light chain of class I major histocompatibility complex, is responsible for the dialysis-related amyloidosis and, in patients undergoing long term dialysis, the full-length and chemically unmodified β2m converts into amyloid fibrils. The protein, belonging to the immunogl...
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Autori principali: | , , , , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820808/ https://ncbi.nlm.nih.gov/pubmed/20028983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061168 |
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