IDH1 and IDH2 Mutations in Gliomas

BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gli...

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Huvudupphovsmän: Yan, Hai, Parsons, D. Williams, Jin, Genglin, McLendon, Roger, Rasheed, B. Ahmed, Yuan, Weishi, Kos, Ivan, Batinic-Haberle, Ines, Jones, Siân, Riggins, Gregory J., Friedman, Henry, Friedman, Allan, Reardon, David, Herndon, James, Kinzler, Kenneth W., Velculescu, Victor E., Vogelstein, Bert, Bigner, Darell D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820383/
https://ncbi.nlm.nih.gov/pubmed/19228619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0808710
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