Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis

OBJECTIVE: In rheumatoid arthritis (RA), telomeres of lymphoid and myeloid cells are age-inappropriately shortened, suggesting excessive turnover of hematopoietic precursor cells (HPC). We have examined functional competence (proliferative capacity, maintenance of telomeric reserve) of CD34(+) HPC i...

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Hlavní autoři: Colmegna, Ines, Diaz-Borjon, Alejandro, Fujii, Hiroshi, Schaefer, Linda, Goronzy, Jörg J., Weyand, Cornelia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820283/
https://ncbi.nlm.nih.gov/pubmed/18383391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23287
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