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Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis
OBJECTIVE: In rheumatoid arthritis (RA), telomeres of lymphoid and myeloid cells are age-inappropriately shortened, suggesting excessive turnover of hematopoietic precursor cells (HPC). We have examined functional competence (proliferative capacity, maintenance of telomeric reserve) of CD34(+) HPC i...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820283/ https://ncbi.nlm.nih.gov/pubmed/18383391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23287 |
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