FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass, whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by activating genes involved in free radical scavenging and apoptosis. Conditional deletion of FoxO1, 3 and 4 in three month-old mice...

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Hauptverfasser: Ambrogini, Elena, Almeida, Maria, Martin-Millan, Marta, Paik, Ji-Hye, DePinho, Ronald A., Han, Li, Goellner, Joseph, Weinstein, Robert S., Jilka, Robert L., O'Brien, Charles A., Manolagas, Stavros C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819984/
https://ncbi.nlm.nih.gov/pubmed/20142101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.12.009
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