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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass, whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by activating genes involved in free radical scavenging and apoptosis. Conditional deletion of FoxO1, 3 and 4 in three month-old mice...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819984/ https://ncbi.nlm.nih.gov/pubmed/20142101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.12.009 |
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