Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Saponin fractions of Quillaja saponaria Molina (QS) have cytotoxic activity against cancer cells in vitro, but are too toxic to be useful in the clinic. The toxic effect was abolished by converting QS fractions into stable nanoparticles through the binding of QS to cholesterol. Two fractions of QS w...

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Bibliografiske detaljer
Main Authors: Hu, Kefei, Berenjian, Saideh, Larsson, Rolf, Gullbo, Joachim, Nygren, Peter, Lövgren, Tanja, Morein, Bror
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2010
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819906/
https://ncbi.nlm.nih.gov/pubmed/20161987
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