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Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line.

We report here the occurrence of homologous recombination between transferred and chromosomal immunoglobulin genes. Specifically, we have corrected a chromosomal immunoglobulin gene mutation by transferring pSV2neo vectors encoding the constant region of the immunoglobulin mu heavy chain to mutant h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Baker, M D, Pennell, N, Bosnoyan, L, Shulman, M J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281986/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2842771/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6432
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