Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line.
We report here the occurrence of homologous recombination between transferred and chromosomal immunoglobulin genes. Specifically, we have corrected a chromosomal immunoglobulin gene mutation by transferring pSV2neo vectors encoding the constant region of the immunoglobulin mu heavy chain to mutant h...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
1988
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2842771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6432 |
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