Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line.
We report here the occurrence of homologous recombination between transferred and chromosomal immunoglobulin genes. Specifically, we have corrected a chromosomal immunoglobulin gene mutation by transferring pSV2neo vectors encoding the constant region of the immunoglobulin mu heavy chain to mutant h...
Salvato in:
| Pubblicato in: | Proc Natl Acad Sci U S A |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1988
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2842771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6432 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|