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Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a contin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819822/ https://ncbi.nlm.nih.gov/pubmed/18479486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1541-0420.2008.01045.x |
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