Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis

Activation of complement occurs during autoimmune retinal and intraocular inflammatory disease as well as neuroretinal degenerative disorders. The cleavage of C5 into fragments C5a and C5b is a critical event during the complement cascade. C5a is a potent proinflammatory anaphylatoxin capable of ind...

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Detaylı Bibliyografya
Asıl Yazarlar: Copland, D A, Hussain, K, Baalasubramanian, S, Hughes, T R, Morgan, B P, Xu, H, Dick, A D, Nicholson, L B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2010
Konular:
Translational Studies
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819496/
https://ncbi.nlm.nih.gov/pubmed/20002447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2009.04070.x
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