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Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein
The poxvirus 2L protein binds tumor necrosis factor-α (TNFα) to inhibit host antiviral and immune responses. The 2.8-Å 2L–TNFα structure reveals three symmetrically arranged 2L molecules per TNFα trimer. 2L resembles class I major histocompatibility complex (MHC) molecules but lacks a peptide-bindin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819277/ https://ncbi.nlm.nih.gov/pubmed/19838188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1683 |
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