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Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor

UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2.2-Å structure of a LIR-1/UL18/peptide complex reveals increased contacts and optimal surface complementarity in the LIR-1/UL18 i...

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Detalhes bibliográficos
Main Authors: Yang, Zhiru, Bjorkman, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2465803/
https://ncbi.nlm.nih.gov/pubmed/18632577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804551105
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