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Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein

The poxvirus 2L protein binds tumor necrosis factor-α (TNFα) to inhibit host antiviral and immune responses. The 2.8-Å 2L–TNFα structure reveals three symmetrically arranged 2L molecules per TNFα trimer. 2L resembles class I major histocompatibility complex (MHC) molecules but lacks a peptide-bindin...

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Bibliografiske detaljer
Main Authors: Yang, Zhiru, West, Anthony P, Bjorkman, Pamela J
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819277/
https://ncbi.nlm.nih.gov/pubmed/19838188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1683
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