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Rational Design of Targeted Cancer Therapeutics through the Multi-Conjugation of Folate and Cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) Copolymers
A well-defined N-(2-hydroxypropyl)methacrylamide-s-N-(3-aminopropyl)methacrylamide (HPMA-s-APMA) copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, was utilized for the rational design of multi-conjugates containing both a gene therapeutic, small inter...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819026/ https://ncbi.nlm.nih.gov/pubmed/20050670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm901249n |
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