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Excision of 5-halogenated Uracils by Human Thymine DNA Glycosylase: Robust Activity for DNA Contexts other than CpG
Thymine DNA glycosylase (TDG) excises thymine from G·T mispairs, and removes a variety of damaged bases (X), with a preference for lesions in a CpG·X context. We recently reported that human TDG rapidly excises 5-halogenated uracils, exhibiting much greater activity for CpG·FU, CpG·ClU, and CpG·BrU...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818988/ https://ncbi.nlm.nih.gov/pubmed/17602166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704253200 |
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