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Excision of 5-halogenated Uracils by Human Thymine DNA Glycosylase: Robust Activity for DNA Contexts other than CpG

Thymine DNA glycosylase (TDG) excises thymine from G·T mispairs, and removes a variety of damaged bases (X), with a preference for lesions in a CpG·X context. We recently reported that human TDG rapidly excises 5-halogenated uracils, exhibiting much greater activity for CpG·FU, CpG·ClU, and CpG·BrU...

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Bibliografske podrobnosti
Main Authors: Morgan, Michael T., Bennett, Matthew T., Drohat, Alexander C.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818988/
https://ncbi.nlm.nih.gov/pubmed/17602166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704253200
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