Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H(+)-conducting fatty acid cycling mediated by penetrating cations such as 10-(6’-plastoquinonyl)decyltriphenylphosphonium (SkQ1) or dodecyltriphenylphosphonium (C(12)TPP). The phenomenon has been...

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Autors principals: Severin, Fedor F., Severina, Inna I., Antonenko, Yury N., Rokitskaya, Tatiana I., Cherepanov, Dmitry A., Mokhova, Elena N., Vyssokikh, Mikhail Yu., Pustovidko, Antonina V., Markova, Olga V., Yaguzhinsky, Lev S., Korshunova, Galina A., Sumbatyan, Nataliya V., Skulachev, Maxim V., Skulachev, Vladimir P.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818959/
https://ncbi.nlm.nih.gov/pubmed/20080732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910216107
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