Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H(+)-conducting fatty acid cycling mediated by penetrating cations such as 10-(6’-plastoquinonyl)decyltriphenylphosphonium (SkQ1) or dodecyltriphenylphosphonium (C(12)TPP). The phenomenon has been...

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Detalhes bibliográficos
Main Authors: Severin, Fedor F., Severina, Inna I., Antonenko, Yury N., Rokitskaya, Tatiana I., Cherepanov, Dmitry A., Mokhova, Elena N., Vyssokikh, Mikhail Yu., Pustovidko, Antonina V., Markova, Olga V., Yaguzhinsky, Lev S., Korshunova, Galina A., Sumbatyan, Nataliya V., Skulachev, Maxim V., Skulachev, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818959/
https://ncbi.nlm.nih.gov/pubmed/20080732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910216107
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