Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis

The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa...

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Detaylı Bibliyografya
Asıl Yazarlar: Bushar, Nicholas D., Corbo, Evann, Schmidt, Michelle, Maltzman, Jonathan S., Farber, Donna L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818906/
https://ncbi.nlm.nih.gov/pubmed/20080760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908126107
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