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2,4-Diamino-5-methyl-6-substituted Arylthio-furo[2,3-d]pyrimidines as Novel Classical and Nonclassical Antifolates as Potential Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors1a,b

A novel classical antifolate N-{4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl}-l-glutamic acid 5 and 11 nonclassical antifolates 6–16 were designed, synthesized, and evaluated as inhibitors of dihydrofolate reductase (DHFR) and thymidylate synthase (TS). The nonclassical compounds...

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Bibliographic Details
Main Authors: Gangjee, Aleem, Jain, Hiteshkumar D., Phan, Jaclyn, Guo, Xin, Queener, Sherry F., Kisliuk, Roy L.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818873/
https://ncbi.nlm.nih.gov/pubmed/20056546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.029
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