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Context-dependent regulatory mechanism of the splicing factor hnRNP L

Splicing regulatory proteins often have distinct activities when bound to exons versus introns. However, less clear is whether variables besides location can influence activity. HnRNP L binds to a motif present in both CD45 variable exons 4 and 5 to affect their coordinate repression. Here we show t...

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Autors principals: Motta-Mena, Laura B., Heyd, Florian, Lynch, Kristen W.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818868/
https://ncbi.nlm.nih.gov/pubmed/20122404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.027
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