Predictive Screening Model for Potential Vector-Mediated Transport of Cationic Substrates at the Blood-Brain Barrier Choline Transporter

A set of semi-rigid cyclic and acyclic bis-quaternary ammonium analogs, which were part of a drug discovery program aimed at identifying antagonists at neuronal nicotinic acetylcholine receptors, were investigated to determine structural requirements for affinity at the blood-brain barrier choline t...

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Detaylı Bibliyografya
Asıl Yazarlar: Geldenhuys, Werner J., Manda, Vamshi K., Mittapalli, Rajendar K., Van der Schyf, Cornelis J., Crooks, Peter A., Dwoskin, Linda P., Allen, David D., Lockman, Paul R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818856/
https://ncbi.nlm.nih.gov/pubmed/20053562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.079
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