P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model

The blood–brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the sealing of vascular endothelial cells together with tight junction proteins to prevent paracellular diffusion. In addition, the BBB has a high deg...

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Bibliographic Details
Main Authors: Adkins, Chris E., Mittapalli, Rajendar K., Manda, Vamshi K., Nounou, Mohamed I., Mohammad, Afroz S., Terrell, Tori B., Bohn, Kaci A., Yasemin, Celik, Grothe, Tiffany R., Lockman, Julie A., Lockman, Paul R.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816283/
https://ncbi.nlm.nih.gov/pubmed/24312053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00136
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