Optimizing Protein Stability In Vivo

Identifying mutations that stabilize proteins is challenging because most substitutions are destabilizing. In addition to being of immense practical utility, the ability to evolve protein stability in vivo may indicate how evolution has formed today's protein sequences. Here we describe a genet...

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Main Authors: Foit, Linda, Morgan, Gareth J., Kern, Maximilian J., Steimer, Lenz R., von Hacht, Annekathrin A., Titchmarsh, James, Warriner, Stuart L., Radford, Sheena E., Bardwell, James C.A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818778/
https://ncbi.nlm.nih.gov/pubmed/20005848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.11.022
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