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In Vivo Detection and Quantification of Chemicals that Enhance Protein Stability
We have devised protein-folding sensors that link protein stability to TEM-1 β-lactamase activity. Addition of osmolytes and other compounds with chemical chaperone activity to the growth media of bacteria containing these sensors increases β-lactamase activity up to 207-fold in a dose-dependent man...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670414/ https://ncbi.nlm.nih.gov/pubmed/23219982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.11.022 |
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