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Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood–brain barrier disruption through matrix metalloproteinase activity
Cyclooxygenases (COX) -1 and -2 are key regulators of innate immune responses. We recently demonstrated that the expression of proinflammatory cytokines and chemokines is reduced in COX-1 null ((−/−)), and increased in COX-2(−/−) mice compared with their respective wild type controls during lipopoly...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818570/ https://ncbi.nlm.nih.gov/pubmed/19844242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.223 |
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