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Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury

Cyclooxygenase (COX)-1 and -2 metabolize arachidonic acid to prostanoids and reactive oxygen species, major players in the neuroinflammatory process. While most reports focused on the inducible isoform, COX-2, the contribution of COX-1 to the inflammatory response is unclear. In the present study th...

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Hlavní autoři: Choi, Sang-Ho, Langenbach, Robert, Bosetti, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386977/
https://ncbi.nlm.nih.gov/pubmed/18162486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-9411com
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