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Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists
HIV-1 viral budding involves binding of the viral Gag(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence “Pro-Thr-Ala-Pro” (“PTAP”). Using the p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818493/ https://ncbi.nlm.nih.gov/pubmed/19914066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.105 |
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