Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists

HIV-1 viral budding involves binding of the viral Gag(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence “Pro-Thr-Ala-Pro” (“PTAP”). Using the p...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Fa, Stephen, Andrew G., Waheed, Abdul A., Freed, Eric O., Fisher, Robert J., Burke, Terrence R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818493/
https://ncbi.nlm.nih.gov/pubmed/19914066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.105
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