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Hydrazone and Hydrazide-Containing N-Substituted Glycines as Peptoid Surrogates for Expedited Library Synthesis: Application to the Preparation of Tsg101-Directed HIV-1 Budding Antagonists
[Image: see text] Replacing the Pro6 in the p6(Gag)-derived 9-mer “P-E-P-T-A-P-P-E-E” with N-substituted glycine (NSG) residues is problematic. However, incorporation of hydrazone amides (“peptoid hydrazones”) can be readily achieved in library fashion. Furthormore, reduction of these hydrazones to...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547129/ https://ncbi.nlm.nih.gov/pubmed/17048869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0622211 |
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