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Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the “late” or “L” domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Demirov, Dimiter G., Ono, Akira, Orenstein, Jan M., Freed, Eric O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117412/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11805336/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.032511899
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