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Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the “late” or “L” domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of...

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Autors principals: Demirov, Dimiter G., Ono, Akira, Orenstein, Jan M., Freed, Eric O.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC117412/
https://ncbi.nlm.nih.gov/pubmed/11805336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032511899
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