Modeling of Human Anti-GBM Antibody–α3(IV)NC1 Interactions Predicts Antigenic Cross-Linking through Contact of Both Heavy Chains with Repeating Epitopes on α3(IV)NC1

BACKGROUND/AIMS: Patients with anti-glomerular basement membrane diseases produce pathogenic autoantibodies (autoAb) that deposit in the kidney and initiate severe inflammation. Restricted antigenic specificity of the autoAb against 2 regions (with related sequences) within α3(IV)NC1, along with sha...

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Bibliografiska uppgifter
Huvudupphovsmän: Meyers, Kevin E.C., Christensen, Mette, Madaio, Michael P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: S. Karger AG 2009
Ämnen:
Original Report: Laboratory Investigation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818399/
https://ncbi.nlm.nih.gov/pubmed/19786737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000242476
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