Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated...

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Detalhes bibliográficos
Main Authors: Olaru, Florina, Wang, Xu-Ping, Luo, Wentian, Ge, Linna, Miner, Jeffrey H, Kleinau, Sandra, Geiger, Xochiquetzal J., Wasiluk, Andrew, Heidet, Laurence, Kitching, A. Richard, Borza, Dorin-Bogdan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563930/
https://ncbi.nlm.nih.gov/pubmed/23303673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202204
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