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An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis

A significant gap exists between genetics-based investigations of polyketide synthases (PKS) and nonribosomal peptide synthetase (NRPS) biosynthetic pathways and our understanding of their regulation, interaction, and activity in living systems. To help bridge this gap, here we present an Orthogonal...

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Autores principales: Meier, Jordan L., Niessen, Sherry, Hoover, Heather S., Foley, Timothy L., Cravatt, Benjamin F., Burkart, Michael D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818308/
https://ncbi.nlm.nih.gov/pubmed/19785476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb9002128
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