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An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis

A significant gap exists between genetics-based investigations of polyketide synthases (PKS) and nonribosomal peptide synthetase (NRPS) biosynthetic pathways and our understanding of their regulation, interaction, and activity in living systems. To help bridge this gap, here we present an Orthogonal...

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Détails bibliographiques
Auteurs principaux: Meier, Jordan L., Niessen, Sherry, Hoover, Heather S., Foley, Timothy L., Cravatt, Benjamin F., Burkart, Michael D.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818308/
https://ncbi.nlm.nih.gov/pubmed/19785476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb9002128
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