SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, matche...

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Autors principals: Nowak, Daniel, Ogawa, Seishi, Müschen, Markus, Kato, Motohiro, Kawamata, Norihiko, Meixel, Antonie, Nowak, Verena, Kim, Han S., Kang, Sharon, Paquette, Ronald, Chang, Mi-Sook, Thoenissen, Nils H., Mossner, Max, Hofmann, Wolf-Karsten, Kohlmann, Alexander, Weiss, Tamara, Haferlach, Torsten, Haferlach, Claudia, Koeffler, H. Phillip
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817631/
https://ncbi.nlm.nih.gov/pubmed/19965645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-210377
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